Mechanism behind PARP1-mediated DNA repair characterized, offering insight into targeted cancer therapy

When DNA is damaged, cellular processes respond and repair the DNA. Inhibiting DNA damage repair can be therapeutically beneficial in cancers with genetic vulnerabilities related to DNA damage response. Scientists at St. Jude Children's Research Hospital have uncovered a mechanism behind how this process works, which may have implications for cancer treatment. The results were published today in Molecular Cell.

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