New DNA sequencing methods detect rare mutations acquired as bodies grow and age

Somatic mutations, the DNA changes that occur as our bodies grow and age, not only hold an important key to cancer but are emerging as the seeds of a wide range of common, noncancerous diseases. The Somatic Mosaicism across Human Tissues (SMaHT) Network, a National Institutes of Health Common Fund initiative to catalog all the normal processes of somatic mutation, has published its first comprehensive benchmarking study in the journal Cell.

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