Same duty cycle, very different outcomes: What tough materials taught us about histotripsy

One of the questions that stayed with me throughout my Ph.D. was surprisingly simple: Why are some tissues so much harder to break down with histotripsy than others? Histotripsy is a focused ultrasound technique that uses cavitation bubbles to mechanically break down tissue. Unlike thermal ablation, the goal is not to heat the tissue. Instead, the rapid activity of these bubbles creates mechanical stresses that progressively disrupt tissue structure.

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