Experiments reveal how DNA-packaging protein mutation promotes breast cancer spread

A research team led by professor Chan Kui-ming from the Department of Biomedical Sciences at CityUHK discovered that H2BE113K, a missense H2B mutation, promotes colony formation and lung metastasis in breast cancer. The research revealed that H2BE113K plays a critical role in chromatin regulation, cellular function and breast cancer progression, shedding light on new targeted therapies for breast cancer.

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