Polyubiquitin may stabilize tau filament structures in neurodegenerative diseases

In neurodegenerative diseases such as Alzheimer's disease, progressive neuronal damage is associated with the accumulation of abnormal tau filaments in the brain. The core of these filaments forms a highly ordered structure, while molecules such as ubiquitin are attached to tau around the core as post-translational modifications. However, the role these peripheral modifications play in maintaining the structural stability of tau filaments remains unclear.

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