Assembly pathway reveals how bacteria build protein coils that extend in acid

The assembly pathway behind refractile-body proteins may have finally been resolved, researchers from Science Tokyo report. Using genetic engineering and several techniques for analyzing protein structure, they investigated how four proteins work together to produce the correct architecture of these complex, pH-responsive protein machines, from the nanoscale to the microscale. The findings could help establish new frameworks for engineering dynamic protein systems as biotechnological tools.

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