Two protective genetic pathways may converge to reduce Alzheimer's disease risk

Alzheimer's disease is the most common form of dementia worldwide. Although the APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease, not all carriers develop dementia, indicating that other genetic factors can modify disease risk. In recent years, PLCG2 has emerged as one of the most important protective genes associated with Alzheimer's disease.

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