Prime assembly can correct multiple mutations at once, pointing toward universal gene therapies

Genomic editing holds great potential yet continues to have limitations. Current methods either rely on untargeted gene delivery or short DNA edits that need to be individualized for each patient. A new paper published today in Nature describes a novel genome engineering method called prime assembly that allows long DNA fragments to be stitched into precise, programmable target positions within living cells. This approach may allow for the development of universal gene therapies that can be used for many patients.

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