Mutation of the MECP2 gene, the main cause of Rett syndrome, alters pubertal development and sex hormones in mice

A research team including personnel from the Departament of Biologia Celullar i Biologia Funcional at the Universitat of València (UV), the Unitat Predepartamental de Medicina at Universitat Jaume I of Castelló (UJI) and Queen Mary University of London (QMUL) has shown that a mutation in the Mecp2 gene alters the function of the hypothalamic-pituitary-gonadal axis, which controls sexual hormone levels, and delays pubertal development in a mouse model of Rett syndrome.

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