MLC1 antibody identified as possible trigger of rare neurological autoimmune disorder

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system in which the immune system attacks structures in the brain, spinal cord and optic nerve. It mostly affects astrocytes, glial cells that have important support and supply functions in nerve tissue. As early as 2005, the majority of patients with NMOSD were shown to have an antibody in their serum that attacks the astrocyte protein aquaporin-4.

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