Genetic tests may miss reaction risk from drug prescribed to millions

A genetic marker already used to flag the risk of a life-threatening reaction to the antibiotic vancomycin also identifies patients at risk of that reaction to lamotrigine—and it is missing from the gene panels clinicians order before prescribing the drug, Vanderbilt Health-led researchers report in JAMA Network Open. The two variants those panels do test for showed no association with lamotrigine reaction in a U.S. population.

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