Dementia with Lewy bodies: Why are some brain regions more affected than others?

Dementia with Lewy bodies is one of the most common forms of dementia in older adults, after Alzheimer's disease. It takes its name from "Lewy bodies," abnormal clumps of a protein called alpha-synuclein, first identified by neurologist Friedrich Lewy, that accumulate inside neurons and contribute to damaging them. The disease manifests through visual hallucinations, fluctuating cognition, agitated and often violent movements during dreams, and motor symptoms similar to those of Parkinson's disease.

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